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Nona Biosciences: Pioneering Biotherapeutic Innovation with Cutting-Edge Technology

Nona Biosciences is a leading global biotechnology company that is revolutionizing the field of biotherapeutic innovation. With their cutting-edge technology and advanced antibody discovery platforms, Nona Biosciences is dedicated to providing comprehensive solutions for partners worldwide. In this article, we will explore the groundbreaking work of Nona Biosciences and the key technologies they employ to drive transformative advancements in the development of therapeutic antibodies.

Nona Biosciences: Advancing Biotherapeutic Innovation

Nona Biosciences has positioned itself at the forefront of biotherapeutic innovation by leveraging state-of-the-art technologies and a highly experienced team. Their integrated antibody discovery services span the entire spectrum of development, from antigen preparation and animal immunization to single B cell screening, antibody lead generation and engineering, developability assessment, and pharmacological evaluation. This comprehensive approach ensures the delivery of high-quality therapeutic antibodies that meet the diverse needs of their partners.

Core Technology: Harbour Mice®

At the heart of nona bio success lies their proprietary Harbour Mice® platform. Harbour Mice® is a clinically validated technology that enables the generation of fully human monoclonal antibodies. This platform produces antibodies in two heavy and two light chains (H2L2) format, as well as heavy chain only (HCAb) format. By harnessing the power of Harbour Mice®, Nona Biosciences can drive the development of next-generation drugs through diversified partnership strategies.

H2L2: Unleashing Antibody Discovery Potential

The H2L2 platform offered by Nona Biosciences represents a powerful tool for antibody discovery. With its global intellectual property protection and clinical validation, H2L2 facilitates the development of highly specific and efficacious antibodies. This versatile platform supports the generation of bi-specific antibodies, chimeric antigen receptor T-cell (CAR-T) therapies, antibody-drug conjugates (ADCs), mRNA-based therapeutics, and diagnostic imaging agents. The flexibility and effectiveness of the H2L2 platform make it a valuable asset in driving innovative therapeutic solutions.

HCAb: Opening New Horizons

Nona Biosciences’ HCAb platform is a unique and highly optimized technology for generating fully human heavy chain only antibodies. It stands as the world’s first fully human HCAb transgenic mouse platform and the first clinically validated fully human HCAb platform. The HCAb platform offers remarkable versatility and finds applications in the development of bi-specific antibodies, payload delivery systems, cell-based therapies, and nanoparticle targeting. By harnessing the capabilities of the HCAb platform, Nona Biosciences is pushing the boundaries of therapeutic innovation.

Antibody Engineering and Beyond

Nona Biosciences goes beyond antibody discovery by providing comprehensive antibody engineering capabilities. Their expertise in affinity maturation, liability engineering, and Fc engineering allows for the optimization of antibodies to enhance therapeutic efficacy and safety. Additionally, Nona Biosciences supports the development of bispecific antibodies, enabling the integration of antibodies with various entities such as proteins, payloads, cells, and nanoparticles. This broadens the scope of therapeutic possibilities and drives innovation in the field.


Nona Biosciences is a trailblazer in the realm of biotherapeutic innovation, driven by cutting-edge technology and a commitment to excellence. Through their advanced Harbour Mice® platform and versatile H2L2 and HCAb technologies, Nona Biosciences is shaping the future of therapeutic antibodies. By offering comprehensive solutions and expertise in antibody discovery and engineering, they empower their partners to develop groundbreaking biotherapeutics. With Nona Biosciences at the forefront, the field of biotechnology is poised for remarkable advancements in the treatment of various diseases and medical conditions.

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